Within the realms of mathematics and science, this is a useful pragmatism. But notice: It’s still a certainty.
Uncertainty about uncertainty would be a level above that.
Even beyond that, there’d just be … well… nothing to us. Might exist, might not but its akin to asking you to use your internal magnetoreception to point me to due North. It’s not one of our senses. Yet, we’re aware of magnetoreception. What of forces and things we’re incapable of being aware of? Can we be certain that we’ll NEVER find out? We still can’t.