I keep both benedryl (clone) + claritin (clone) on hand for oddball reactions. I don’t get them much, but if in doubt, getting the over-excited histamines to calm the heck down is usually a good step and safe enough.
Benedryl would be if I’m not far off from sleep time, and claritin if I need to be up.
Then I pop a zinc (50mg or whatever standard daily dose it) to give my white blood cells a little punch. I’m just glad I don’t have any major issues in that area but I honestly don’t like any.