Does the Holy Spirit Proceed from the Father or from the Father _and_ the Son?
That’s one of the reasons for the split.
Another is the Roman Church claim of being Supreme rather than a council of equals.
But for me when I was involved, the biggest distinction was one of the things that really drew me into Orthodoxy at the time vs any others: The Essence vs Energies. It helped clarify the medicinal nature of faith and the transfiguration of matter