Change is made where the pain is felt.
I can’t remember the expression exactly but it’s a good sentiment. In businesses, this notion is used when doing forensic analysis (what went right and wrong in a project after it’s done). You identity the sources of pain in the project, which are usually departments that were either under or overutilized in the process, or used incorrectly, and then work with that department to make appropriate changes for the future.
If done properly, the organization as a whole becomes healthier and more functional for future projects.
I’ve also seen it used as a sentiment expressing the “driving force” of change itself, a transformational force that can completely overturn a larger structure and change it into something entirely different or improve it in significant ways.